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Research Bioinformatician I

Los Angeles, California

Overview

Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. By joining us in an academic role, you’ll be a part of formulating future ideas for discovery and then translating those discoveries into cures for the benefit and health of the Los Angeles community.

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Success Profile

What makes a successful Research Bioinformatician I at Cedars-Sinai? Check out the traits we’re looking for and see if you have the right mix.

  • Analytical
  • Organized
  • Deadline-oriented
  • Adaptable
  • Results-driven
  • Problem-solver

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Culture

Discovery is central to Cedars-Sinai’s mission. Our laboratories and clinics generate ideas, therapies, devices, and systems that contribute to biomedical progress around the world. Cedars-Sinai’s investigators push the frontiers of biomedicine with studies in cardiac care, cancer, digestive health, the neurosciences, women’s health, and more. Cedars-Sinai’s robust academic enterprise shapes the experts who will help redefine medicine for the next generation.

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Responsibilities

Requisition # HRC0865041

Cancer Research Breakthroughs Begin with Employees Like You

The Merchant Laboratory is studying how tumor cells interact with their microenvironment and how this interaction contributes to the development and maintenance of cancer. In particular, the Merchant Lab is interested in how immune cells are trafficked into the tumor space and how immune cells can be harnessed to treat cancer.

Are you ready to apply your skills?

The Merchant lab is seeking a Research Bioinformatician I who can provide bioinformatics analysis of imaging mass cytometry (IMC). Our lab runs the imaging mass cytometry/CyTOF core facility at Cedars-Sinai. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution. Imaging mass cytometry can be applied to all tissue types including cell lines, organoid, frozen section and FFPE fixed archival tissue. Experience with digital pathology, multiplex immunohistochemistry, CyCIF, image analysis, and/or GIS analysis would be highly preferred. Collaborations with other investigators at Cedars-Sinai allows access to data from single cell RNAseq, mass spec proteomics, and metabolic studies of immune cells. The goal is to generate publications and presentations that will advance the field of cancer immunology. Other opportunities to study computational and bioinformatic problems related to COVID-19 and T-cell receptor sequencing are available.

In addition, the Research Bioinformatician will be responsible for the following:

  • Provides general bioinformatics analysis support for IMC projects, assist in development, testing and maintenance of software pipelines for IMC data analysis, statistical analysis, pathway analysis, and visualization.
  • Summarizes data analyses results in the form of visualization plots & reports to aid in preliminary interpretations of the data.
  • Software-engineering to improve usability, extensibility and scalability of existing programs including development of custom software interfaces & automation/optimization/parallelization of tasks.
  • Helps to identify, evaluate, and incorporate relevant algorithms and software pipelines by reviewing pertinent literatures in bioinformatics and computational biology.
  • Works with the PI and core collaborators on standard and complex research projects to customize analysis of data.
  • Develop web-based custom analytics and data management applications and tools to facilitate large-scale data analysis.

Education:

  • Bachelor OR Master of Science Degree in Computer Science, Electric Engineering, Computational biology, or Bioinformatics, or Bachelor or Master of Science/ Engineering in relevant fields (e.g. Biology with strong quantitative training, biostatistics with concentration in bioinformatics)

Experience:

  • Minimum 2 years of experience in a research environment.
  • Background and work knowledge in algorithms, scientific computing, and machine learning or statistics.
  • Familiar with python, R and the Unix (Linux) environment
  • Experience in manipulating, analyzing, and annotating large data sets both in exploratory and pipelined fashions
  • Working Title: Research Bioinformatician I
  • Department: Home Dept - Hem - Onc
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic/Research
  • Job Specialty: Bioinformatics
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu) and COVID-19. For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through April each year) as a condition of employment, and annually thereafter as a condition of continued employment, subject to medical exemption or religious accommodation. For the same reason, you may also be required to receive other vaccines such as COVID-19 as a condition of employment. Cedars-Sinai reserves the right to make modifications to its required list of vaccines as required by law and/or policy.

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Rewards

Discover all the ways Cedars-Sinai appreciates your efforts.

  • Healthcare

  • 401(K)/Retirement Plans

  • Continuing Education

  • Relocation Reimbursement

  • Professional Development

  • Work/life Balance

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