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Research Associate II - Gayther Lab

Los Angeles, California

Overview

Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. By joining us in an academic role, you’ll be a part of formulating future ideas for discovery and then translating those discoveries into cures for the benefit and health of the Los Angeles community.

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Success Profile

What makes a successful Research Associate II - Gayther Lab at Cedars-Sinai? Check out the traits we’re looking for and see if you have the right mix.

  • Analytical
  • Organized
  • Deadline-oriented
  • Adaptable
  • Results-driven
  • Problem-solver

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Culture

Discovery is central to Cedars-Sinai’s mission. Our laboratories and clinics generate ideas, therapies, devices, and systems that contribute to biomedical progress around the world. Cedars-Sinai’s investigators push the frontiers of biomedicine with studies in cardiac care, cancer, digestive health, the neurosciences, women’s health, and more. Cedars-Sinai’s robust academic enterprise shapes the experts who will help redefine medicine for the next generation.

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Responsibilities

Requisition # HRC0814404A

Principal Investigator, Simon Gayther, PhD, is looking for a Research Associate to join their lab!

Research in the Gayther laboratory is focused largely on understanding the underlying causes of ovarian cancer initiation and development. The overall approach of this research program is to integrate genomics and epigenomics analyses to identify molecular markers associated with disease, with cell biology modeling studies to validate the role of novel molecular markers in disease biology. To learn more, please visit Gayther Research Lab | Cedars-Sinai.

Are you ready to be a part of breakthrough research?

Working under the supervision of the Principal Investigator and Center Director, the Research Associate II (RAII) performs routine and increasingly complex laboratory tasks and procedures and develops technical expertise in one or more areas relevant to research projects. The RAII will participate in research activities involving all aspects of the research process, including, but not limited to; investigation, technical, testing/validation of results, and report findings. The RAII is expected to work with other members of the research team, which specifically includes molecular and cell biologists, genomicists, and computational biologists studying the pathogenesis of breast and ovarian cancers. Projects are focused on functionally modeling different combinations of genetic perturbations in precursor cell types of breast and ovarian cancers, followed by next-generation sequencing and molecular profiling to identify genes that drive the earliest stages of neoplastic development. The goal is to identify biomarkers that represent novel targets for screening, early detection, and chemo-prevention of breast and ovarian cancers.

The Research Associate II will perform a variety of experimental protocols and procedures to support the objectives of these research projects including (but not restricted to) CRISPR/Cas 9 screens, molecular cloning, phenotypic screens, RNA sequencing at other relevant next-generation sequencing methods. The RAII is expected to observe and comply with safety standards and procedures, assist in the preparation of data for publication, the presentation of data internally and at scholarly meetings, and assist in general laboratory maintenance. This position does not have supervisory responsibilities.

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Primary Job Duties and Responsibilities:

  • Performs a variety of increasingly sophisticated experimental protocols and procedures and assist in the design of new complex or unusual protocols and techniques.
  • Keeps accurate and detailed records of experiments and results, and assist in identifying and troubleshooting unexpected results.
  • Orders laboratory supplies and supports laboratory operations.
  • Maintains lab equipment and related records and may coordinate the use of lab equipment.
  • Assists in the operation of specialized equipment, as required by the area of research.
  • Orients research laboratory assistants or lower-level research associates and undergraduate student researchers on day-to-day lab operations and routine procedures.

Department-Specific Responsibilities:

  • Assist with the organization and carry out research projects as directed by the Principal Investigator and/or other designated members of the research team.
  • Assist in monitoring and ensuring compliance with safety standards and procedures.
  • Assist with analyzing data and preparation of scientific findings for publication and presentations.
  • Contribute to research discussion from other members of the research team.
  • Implement and optimize new laboratory methods under the supervision of a designated investigator.
  • Abide by IRB proposals and protocols relating to projects in the laboratory.
  • Abide by Animal Licenses and protocols related to projects in the laboratory.
  • Undertake research projects under the direction of the Principal Investigator or other designated investigators in the research team.

Education:

  • Minimum of a Bachelor of Science or Bachelor of Arts degree in biological science required. Master of Science Degree in a relevant subject preferred.

Experience and Skills:

  • At least one (1) year of research laboratory experience in the area of research specialization, is required. Understanding of general research objectives.
  • Experience and knowledge in areas of molecular biology/biochemistry/cancer biology/cell biology/genetics/genomics.
  • Experience in cell culture and molecular biology.
  • Knowledge and basic skills in cell and molecular biology techniques, such as PCR, RT-PCR and western blotting, immunofluorescence, FACS, Flow Cytometry.
  • Knowledge and basic skills in Microsoft Office software, such as Word, Excel, Power Point etc.
  • Experience in computational analyses of RNA and DNA sequencing files
  • Technical skills and expertise in specified areas of study including RNA, DNA and protein-related work, cell culture, and molecular biology (e.g. PCR, cloning).
  • Expertise in computational analyses, animal modeling of disease, or histology is preferred.
  • Excellent organization good problem-solving skills, detail-oriented, and self-motivated with the ability to multitask.
  • Ability to work closely and effectively within a team environment, with the ability to work well independently on specified projects.
  • Strong interpersonal skills for interaction with peers and other scientists in the research team as well as with the administrative team within the Center.
  • Superior technical and theoretical understanding of Principal’s Investigators research objectives and have the ability to research, develop and implement new laboratory procedures and protocols.
  • Working Title: Research Associate II - Gayther Lab
  • Department: BMS - Bioinfo & Func Genomics
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic/Research
  • Job Specialty: Research Studies/Clinical Trials
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu) and COVID-19. For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through April each year) as a condition of employment, and annually thereafter as a condition of continued employment, subject to medical exemption or religious accommodation. For the same reason, you may also be required to receive other vaccines such as COVID-19 as a condition of employment. Cedars-Sinai reserves the right to make modifications to its required list of vaccines as required by law and/or policy.

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  • Healthcare

  • 401(K)/Retirement Plans

  • Continuing Education

  • Relocation Reimbursement

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