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Research Associate I - Merchant Lab - Cancer Institute

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Requisition # HRC0449122

Principal Investigator, Akil Merchant, MD is looking for a Research Associate I to join the team!

When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it’s just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report.

The Merchant Laboratory is studying how tumor cells interact with their microenvironment and how this interaction contributes to the development and maintenance of cancer.

 

Are you ready to be a part of breakthrough research?

The Merchant lab seeks a Research Associate I with and interest in hematopoiesis, stem cell biology, and/or myeloproliferative diseases to join an NIH funded project examining the role of Hedgehog signaling in the bone marrow microenvironment. Studies in the lab make use of transgenic mouse models and primary patients samples. There will be additional opportunities to study patient samples from patients treated with hedgehog inhibitors. Studies of the bone marrow microenvironment will be enabled but the use of imaging mass cytometry/CyTOF. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution making it the ideal technology for studying stem cells and immune cells in their cellular niches within the bone marrow.

 

Primary Job Duties and Responsibilities:

  • Breeding, genotyping, blood sampling and bone marrow harvesting from transgenic mice.
  • Apply standard molecular and cellular biology methods (RT-PCR, Western bloting, cell culture and transduction, expression profiling) to profile the hedgehog signaling pathway.
  • Performs conjugations and validation of antibodies and other reagents used for mass cytometry work.
  • Uses imaging mass cytometry to study the bone marrow microenvironment and stromal cell changes in animal models of myelofibrosis and in patient samples.
  • Maintains computer database with relevant information.
  • Performs lab maintenance duties, including glassware cleaning and sterilization.
  • Maintains stocks of general lab materials, and places orders for lab equipment and supplies.
  • Assists new students and fellows at the laboratory.
  • Assists in the operation of specialized equipment and machinery including mass cytometry system.
  • Observes and complies with safety standards and procedures.
  • Keeps accurate and detailed project records of experiments and results.
  • Follows, updates and occasionally prepares laboratory SOP.

 

 

Education:

  • Bachelor of Science or Bachelor of Arts degree in biological sciences.

Experience and Skillset:

  • Experience with flow cytometry.
  • Understanding of general research objectives.
  • Familiar with routine laboratory procedures, experimental protocols, and overall lab organization.
  • Ability to work in a team environment.
  • Working Title: Research Associate I - Merchant Lab - Cancer Institute
  • Department: Home Dept - Hem - Onc
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic/Research
  • Job Specialty: Research Studies/Clinical Trials
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu). For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through March each year) as a condition of employment, and annually thereafter as a condition of continued employment.

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