Project Scientist - Translational Cancer Biology and Therapeutics
Los Angeles, California
Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. By joining us in an academic role, you’ll be a part of formulating future ideas for discovery and then translating those discoveries into cures for the benefit and health of the Los Angeles community.
- Full-time & Per-Diem
- Level: Mid to Senior
- Travel: Minimal (if any)
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What makes a successful Project Scientist - Translational Cancer Biology and Therapeutics at Cedars-Sinai? Check out the traits we’re looking for and see if you have the right mix.
Discovery is central to Cedars-Sinai’s mission. Our laboratories and clinics generate ideas, therapies, devices, and systems that contribute to biomedical progress around the world. Cedars-Sinai’s investigators push the frontiers of biomedicine with studies in cardiac care, cancer, digestive health, the neurosciences, women’s health, and more. Cedars-Sinai’s robust academic enterprise shapes the experts who will help redefine medicine for the next generation.
ResponsibilitiesRequisition # HRC0800223A
The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in cancer biology and therapeutics. These contributions include discovery and development a “first in class” RalGTPase inhibitor as a new therapeutic in several human cancer types (Nature. 2014 20;515(7527):443-7). Using functional genomics/synthetic lethal screens (including CRISPR, shRNA and cDNA library use) and single cell and spatial transcriptomics on human cell lines and tumor tissues we have identified several candidate genes that confer resistance to commonly used chemotherapeutics and immunotherapy (i.e. checkpoint inhibitors, Science Advances. 2019 Feb 20;5(2), Nature Commun. 2021; 12;12(1)) in bladder cancer and other tumors. We are seeking a highly motivated research scientist / postdoctoral fellow / postdoc to further develop this work by defining the mechanism of action of how these genes alter resistance to chemotherapeutics, targeted small molecules and biological agents (antibodies, peptides etc…) directed at either the cancer cell or the tumor microenvironment / TME (e.g. immunotherapy, checkpoint inhibitors). The laboratory has ongoing discovery projects directed at key molecules driving cancer growth, metastasis, and tumor microenvironment (TME, stroma/fibroblast) which are being evaluated as candidates for therapeutic targeting and clinical translation to trials in patients.
This individual will join our exciting cancer research group! The successful candidate will be a driven, creative, team-oriented individual with a passion for helping to discover and move fundamental cancer biologic findings towards a clinical setting.
The candidate will have a PhD or MD/PhD degree and background in functional genomics (including CRISPR, shRNA and cDNA library use) and next generation sequencing. A broad-based knowledge of cancer biology, immunology and signal transduction is an important characteristic of the successful applicant.
Strong preference will be given to individuals with an outstanding publication record from prior graduate and/or postgraduate training and/or existing external funding.
For more information please visit: https://www.cedars-sinai.edu/Research/Research-Labs/Theodorescu-Lab/
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:
- Designs and performs experiments. Keeps detailed experimental records and documentation and analyze the results with the Principal Investigator.
- Develops, adapts, and implements new research techniques and protocols.
- Analyzes, interprets, summarizes and compiles data.
- Performs routine and complex laboratory procedures throughout training period including work with mice as needed.
- Assists in preparation of grant proposals but is not responsible for generating grant funds.
- Participates in publications and presentations as author or co-author.
- Meets with PI on a regular basis to discuss research progress and plans.
- May be asked to write fellowship grant proposals such as NRSA/T32 applications.
- Spends about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research.
EDUCATION AND EXPERIENCE REQUIREMENTS:
- Doctorate (PhD or MD/PhD) in immunology or area directly related to field of research specialization.
- Ability to work semi-independently on research projects within an area of specialization.
- Demonstrates aptitude to perform experimental protocols and procedures, including detailed data collection and analysis.
Applicants are recommended to submit materials listed below to Dr. Dan Theodorescu at firstname.lastname@example.org.
- Cover letter that includes the applicants’ career accomplishments and future goals
- Complete curriculum vitae that includes the names and email addresses of three academic references.
- Working Title: Project Scientist - Translational Cancer Biology and Therapeutics
- Department: Cancer Institute
- Business Entity: Academic / Research
- City: Los Angeles
- Job Category: Academic/Research
- Job Specialty: Research Studies/Clinical Trials
- Position Type: Full-time
- Shift Length: 8 hour shift
- Shift Type: Day
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