Postdoctoral Scientist/Research Fellow - Smidt Heart Institute - Marbán Lab
Los Angeles, California
Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. By joining us in an academic role, you’ll be a part of formulating future ideas for discovery and then translating those discoveries into cures for the benefit and health of the Los Angeles community.
- Full-time & Per-Diem
- Level: Mid to Senior
- Travel: Minimal (if any)
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What makes a successful Postdoctoral Scientist/Research Fellow - Smidt Heart Institute - Marbán Lab at Cedars-Sinai? Check out the traits we’re looking for and see if you have the right mix.
Discovery is central to Cedars-Sinai’s mission. Our laboratories and clinics generate ideas, therapies, devices, and systems that contribute to biomedical progress around the world. Cedars-Sinai’s investigators push the frontiers of biomedicine with studies in cardiac care, cancer, digestive health, the neurosciences, women’s health, and more. Cedars-Sinai’s robust academic enterprise shapes the experts who will help redefine medicine for the next generation.
ResponsibilitiesRequisition # HRC0810683
The Marbán Laboratory focuses on two disease themes. The first builds on the long-standing interest of Eduardo Marbán, MD, PhD, in the molecular basis of excitability to create novel, biologically based treatments for cardiac arrhythmias.
The Marbán Lab was the first to create a de novo biological pacemaker, work that is now proceeding toward first-in-human clinical testing. The laboratory is also developing extracellular vesicles as therapeutic agents for refractory ventricular tachycardia.
The second broad category of research in the Marbán Laboratory is in cell therapy and regenerative medicine, which the team has pursued for 16 years. The Marbán Lab was first to isolate and characterize a type of adult progenitor cell known as cardiosphere-derived cells (CDCs), which are now in advanced clinical trials. The first manuscripts defined the engraftment, differentiation and functional benefit of CDCs in murine and porcine models of myocardial infarction. Subsequently, the work has gone from proof of concept through completion of five clinical trials in patients with heart failure and/or Duchenne muscular dystrophy. These trials include ALLSTAR (the ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration trial for moderate heart failure after myocardial infarction) and HOPE-Duchenne (the Halt cardiomyOPathy progrEssion in Duchenne muscular dystrophy trial). Two additional clinical trials of allogenic CDCs—Regress-HFpEF (Regression-Heart Failure with Preserved Ejection Fraction trial for heart failure with preserved ejection fraction) and ALPHA (ALlogeneic CDCs for Pulmonary Hypertension therApy)—are ongoing.
In the process of characterizing CDCs, the laboratory has shown that the mechanism of benefit is largely indirect, mediated by the secretion of extracellular vesicles (exosomes). CDC exosomes are currently being developed as next-generation therapeutic candidates for a variety of clinical indications. A major effort currently in the lab is mining the contents of CDC exosomes to identify defined noncoding RNA species, which may themselves be viable therapeutic candidates. Work in the lab spans from mechanistic discovery science through advanced clinical trial design and analysis, a continuum to which trainees are rigorously exposed.
We are actively seeking a Postdoctoral Scientist/Research Fellow who will work independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientists. In this role, you will perform routine and complex laboratory procedures throughout training period and you may develop, adapt, and implement new research techniques and protocols. Will analyze and interpret data and may assist in preparation of grant proposals. Participates in publications and presentations as author or co-author. You will not be responsible for generating grant funds.
ESSENTIAL JOB DUTIES AND RESPONSIBILITIES:
- May assist in preparation of grant proposals, but is not responsible for generating grant funds.
- May participate in publications and presentations as author or co-author.
- Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
- May develop, adapt, and implement new research techniques and protocols.
- Analyzes, interprets, summarizes and compiles data.
- Performs routine and complex laboratory procedures throughout training period.
- Operates and maintains equipment and instruments
- Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization is required
- Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
- Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
- Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.
- Knowledge of safety standards and maintenance of specialized equipment.
- Working Title: Postdoctoral Scientist/Research Fellow - Smidt Heart Institute - Marbán Lab
- Department: Heart Institute Operations
- Business Entity: Academic / Research
- City: Los Angeles
- Job Category: Academic/Research
- Job Specialty: Postdoctoral
- Position Type: Full-time
- Shift Length: 8 hour shift
- Shift Type: Day
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