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Postdoctoral Scientist – Non-classical mechanisms of therapy resistance, Cancer Institute

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Requisition # HRC0118188B

When the work you do every single day has a crucial impact on the lives of others, every effort, every detail, and every second matters. This shared culture of happiness, passion, and dedication pulses through Cedars-Sinai, and it’s just one of the many reasons why we rank as one of the top hospitals in the nation by U.S. News & World Report.

Are you ready to be a part of breakthrough research?

In this role, the Postdoctoral Scientist will be expected to work independently under the direction of the Principal Investigator (P.I.) and in close cooperation, as well as consultation, with other research staff.

Dr. Keith Syson Chan’s laboratory is seeking a postdoctoral scientist to investigate non-classical mechanisms of therapy resistance, including but not limited to cell death-induced cancer stem cell repopulation [Nature 517, 209–213(2015) https://rdcu.be/cikEy], and immunosuppression [Nature Communications 11: 6299 (2020) https://rdcu.be/cikEQ]. This project will study cancer stem cells and differentiated cells by single cell real-time imaging and other single cell molecular technologies to dissect their epigenetic regulation during tumor repopulation and therapy resistance.

Ideal applicant will be a self-motivated individual who is enthusiastic to interact with other lab members and the PI, he/she is most welcome to bring new ideas to drive project directions. Expertise in epigenetic regulation of normal or cancer stem cells, with extensive experience in FACS, molecular biology knowledge in constructing lentiviral vectors, and organoid culture highly preferred.

KS Chan lab is comprised of an interdisciplinary team https://www.research4cure.org, focusing on cancer research that can translate into early-phase clinical trials or biomarkers to impact patients. We integrate cutting edge single-cell technologies and various study models (e.g., patient-derived xenografts, syngeneic murine models, GEMM) to address key research questions spanning: i) cell death-induced non-classical mechanisms of therapeutic resistance, ii) primary tumor and metastatic niche, and iii) emerging immunologic concepts that impact tumor progression and immune checkpoint response.

To learn more:

Primary Duties and Responsibilities:

  • The design of research directions and experiments in cooperation with the mentor. Will keep appropriate experimental records and analyze the results with the PI. Typical daily experimental activities include FACS, 2D/3D culture, animal models and drug treatment studies.
  • Explore literature and state-of-the-art techniques relevant to the project.
  • Compile figures and text for the submission of publications and presentations as primary author or co-author.
  • Highly encouraged to apply for fellowship or career transition grant application for career advancement.
  • Participate and present at lab meetings, research-oriented interest groups, and attend departmental or cancer center seminar series

Education:

  • Doctorate (MD, PhD, VMD, or DDS) in biomedical sciences, cancer biology or immunology.
  • Working Title: Postdoctoral Scientist – Non-classical mechanisms of therapy resistance, Cancer Institute
  • Department: Home Dept - Hem - Onc
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic/Research
  • Job Specialty: Postdoctoral
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day

Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu). For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through March each year) as a condition of employment, and annually thereafter as a condition of continued employment.

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