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Postdoctoral Scientist - Koltsova Lab - Cancer InstituteRequisition # 20002880 Apply Now
Cedars-Sinai researchers are seeking more effective ways to diagnose, treat and prevent many forms of cancer. Key areas include cancer biology, population science, and experimental therapies.
Join us and be a part of our team!
The Koltsova Lab is interested to define and characterize the role of cytokines in the control of microbiota-driven, metabolic and cellular mechanisms helping to regulate immune cell activation and inflammation in various immune-mediated pathologies such as atherosclerosis, AAA, obesity and cancer.
Chronic low-grade inflammation is a key component in various diseases, including cardiovascular diseases, obesity and cancer. Its becoming increasingly clear that chronic inflammation can be driven by changes in microbiota composition and function, affecting the production of metabolites, which in turn regulate the activation of various immune cells. Therefore dietory and environment factors as well as homeostasis of intestinal epithelial cells can be directly implicated into the pathogenesis of various immune-mediated diseases.
A growing body of evidence demonstrated that cardiovascular diseases (CVD), including atherosclerosis and abdominal aortic aneurysm (AAA) are chronic inflammatory diseases of the arterial wall with a large and previously underappreciated contribution of immune system into disease initiation and progression. Immune system plays a dual role in cancer: while chronic and tumor-elicited inflammation promote tumor growth, anti-cancer immune response is crutial for cancer protection. Obesity is associated with chronic low-grade inflammation and predisposes to many cancers, worsening their prognosis. Most notably, obesity overwhelmingly promotes liver and colon cancers. Cytokines are key regulators of inflammation and important players in auto-inflammatory diseases. Cytokines play an important role in the regulation of intestinal microbiota, production of various metabolites, which in turn contribute to immune cell activation and chronic inflammation. Cytokines are also important regulators of the bone marrow hematopoietic stem cells and mature immune cells production, which represents an important arm of the immune system function.
The Postdoctoral Scientist - Koltsova Lab will perform routine and complex laboratory procedures throughout training period in the field of cancer biology. May develop, adapt, and implement new research techniques and protocols. and interprets data. May assist in preparation of grant proposals. Responsible for designing experiments, assembling data for publications and presentations as author or co-author. Not responsible for generating grant funds.
In addition, the postdoctoral scientist will also be responsible for the following:
- Responsible for the design of experiments in cooperation with the mentor.
- Responsible for compiling figures and text for the submission of publications and presentations as author or co-author.
- Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the mentor.
- Operates and maintains equipment and instruments.
Doctorate (MD, PhD, VMD, or DDS) in in biomedical sciences, pharmacology, or an area directly related to field of research specialization, with demonstrable laboratory experience in drug discovery and natural products research, and in vivo mouse models for antitumor efficacy and pharmacology
- Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
- Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
- Experience as a first author in one or more publications on impactful body of work.
- Demonstrable laboratory experience (1-4 years) in drug discovery and natural products research, in vivo mouse work, antitumor efficacy, and pharmacology, with some experience in molecular biology, tumor cell biology, microbiology, and protein purification and production
- Immune-mediated mechanisms regulating cardiovascular diseases (CVD) development.
- Cytokines in the regulation of intestinal microbiota, metabolites and inflammation in cardiovascular diseases (CVD), adipose tissue inflammation and cancer
- The role of cytokines in stress hematopoiesis in the bone marrow: implication to CVD and cancer.
- Cytokines, cancer immunology and anti-cancer immunity.
Knowledge, Skills, Abilities:
- Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.
- Knowledge of safety standards and maintenance of specialized equipment.
- Ability to function in a team environment and use interpersonal skills to communicate effectively.
- Working Title: Postdoctoral Scientist - Koltsova Lab - Cancer Institute
- Department: Home Dept - Hem - Onc
- Business Entity: Academic / Research
- City: Los Angeles
- Job Category: Academic/Research
- Job Specialty: Postdoctoral
- Position Type: Full-time
- Shift Length: 8 hour shift
- Shift Type: Day
Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.
Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.
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