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Postdoctoral Scientist - Drug Discovery - Cancer Institute

Requisition # 19002007 Apply Now

The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in the area of drug discovery. These contributions include discovery and development a “first in class” RalGTPase inhibitor as a new therapeutic in several human cancer types (Nature. 2014 20;515(7527):443-7). Using functional genomics screens (including CRISPR, shRNA and cDNA library use) and transcriptomics on human cell lines and tumor tissues we have identified several candidate genes that confer resistance to commonly used chemotherapeutics in bladder cancer and other tumors. We are seeking a highly motivated individual to further develop this work by defining the mechanism of action of how these genes alter resistance to such drugs such as cisplatinum, gemcitabine and others including small molecules. The laboratory has ongoing drug discovery projects directed at key molecules involved in cancer biology which may be leveraged and directed at these various candidate genes depending on the interest and ability of the candidate as well as biological findings of the putative targets.


Essential job Duties and Responsibilities:

 

Designs and performs experiments. Keeps detailed experimental records and documentation and analyze the results with the Principal Investigator. 

 

Develops, adapts, and implements new research techniques and protocols.

 

Analyzes, interprets, summarizes and compiles data. 

 

Performs routine and complex laboratory procedures throughout training period.

 

Assists in preparation of grant proposals, but is not responsible for generating grant funds.

 

Participates in publications and presentations as author or co-author.

 

Meets with PI on a regular basis to discuss research progress and plans. 

 

May be asked to write small grant proposals or NRSA/T32 applications.

 

Spends about 75% of time on bench research experimentation and 25% of time on writing articles/analyzing data/online research.


Education:      

Doctorate (PhD or MD/PhD) in molecular biology, or area directly related to field of research specialization.


Experience:

Has the ability to works semi-independently on research projects within an area of specialization. Has thorough technical and theoretical knowledge of research project and the objectives to be accomplished during the one to five (1-5) year post-doctoral appointment. Demonstrates aptitude to perform experimental protocols and procedures, including detailed data collection and analysis.


  • Working Title: Postdoctoral Scientist - Drug Discovery - Cancer Institute
  • Department: Home Dept - Hem - Onc
  • Business Entity: Academic / Research
  • City: Los Angeles
  • Job Category: Academic / Research
  • Job Specialty: Postdoctoral
  • Position Type: Full-time
  • Shift Length: 8 hour shift
  • Shift Type: Day
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Cedars-Sinai is an EEO employer. Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu). For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through March each year) as a condition of employment, and annually thereafter as a condition of continued employment.

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Los Angeles, California

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