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Biomedical Specialist - Applied Genomics, Computation & Translational Core

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Requisition # HRC1224644

The Applied Genomics, Computation & Translational Core is looking for a Biomedical Specialist to join the team!

The Cedars-Sinai Applied Genomics, Computation, and Translational Core (AGCT Core) is a fully equipped, state-of-the-art genomics facility offering data generation and interpretation for basic science and translational research in next-generation sequencing technologies, including single cell omics, spatial transcriptomics, and bulk cell omics. We specialize in single cell omics and spatial transcriptomics via the 10x Genomics, Parse Biosciences, Mission Bio, and NanoString platforms. Our R&D team offers sample preparation for single cell assays, such as nuclei isolation from frozen tissue or single cell isolation from fresh tissue dissociation. The AGCT Core also offers comprehensive services for standard bulk cell sequencing in genomics, transcriptomics, epigenomics, and metagenomics. To learn more please visit Applied Genomics, Computation & Translational Core | Cedars-Sinai.

Are you ready to be a part of breakthrough research?

The Genomics Core Biomedical Specialist is responsible for carrying out wet lab procedures involving DNA/RNA isolation from various sources such as cells, tissue, FFPE curls and scrapes, and blood. In addition, they possess expertise in the complete Next-Generation Sequencing (NGS) workflow, which includes DNA/RNA quantification and quality control (QC) analysis, manual library preparation, library quantification and QC analysis, sequencing on the Illumina platform, and analysis of sequencing metrics.

As part of their duties, the Biomedical Specialist will ensure accurate and up-to-date electronic documentation using an electronic lab notebook, project management software, and laboratory information management system. They will also manually prepare libraries for bulk cell, single cell, and spatial omics, covering transcriptomics (RNA-Seq), genomics (WGS/WES), epigenomics (WGBS, ATAC-Seq), and metagenomics (16S/ITS amplicon sequencing, shotgun).

Overall, this position involves hands-on work in a wet lab environment, focusing on DNA/RNA isolation and various aspects of the NGS workflow, as well as documentation and library preparation for different omics applications.

Primary Duties and Responsibilities:

  • Train, guide, and supervise a team of junior associates.
  • Train and supervise junior associates on Next-Generation Sequencing experiments, procedures, and day-to-day service request fulfillment and lab operations.
  • Effectively communicate needs and requirements to junior associates as required for the management of service requests and day-to-day lab operations.
  • Manage junior associate performance, mentor and coach, and seek opportunities to help them grow and become their best.
  • Assign service requests to junior associates and ensure their proper execution and successful completion.
  • Ensure the availability of all required resources for the execution of service requests.
  • Liaise with investigators regarding service requests.
  • Participate in the planning, execution, and troubleshooting of service requests.
  • Provide research and input on new technologies and assays for testing to possibly develop and implement new service offerings.
  • Execute or manage the execution of projects testing new technologies, assays, or kits.
  • Analyze, summarize, and present findings at monthly R&D meetings.
  • Assist with the implementation of new technologies, assays, or kits into new service offerings by writing and reviewing standard operating procedures, service guidelines, and staff training guides, and training junior associates.
  • Receive, store, and document samples.
  • Attend meetings and seminars/webinars as assigned.

Education:

  • Bachelor of Sciences in Genetics, Genomics, Molecular Biology, or Biological Sciences is required. Master's degree is preferred.

Experience & Skills:

  • Two (2) years of laboratory experience are required. Five (5) years is preferred.
  • Minimum 3 years of experience performing NGS library preparation in bulk cell genomics, transcriptomics, and metagenomics.
  • Minimum 2 years of experience in the operation of Illumina sequencers and Agilent Technologies fragment analyzers.
  • Minimum 1 year of supervisory and training experience.
  • Experience in single cell NGS assays and cell biology is preferred.
  • Critical analysis, problem-solving, troubleshooting, multitasking, time management, following through tasks with details, working independently with minimal supervision.
  • Interact with professionalism with teammates, peers, researchers, investigators, and support staff of diverse backgrounds and educational levels.
  • Respond to rapidly changing priorities and exceptionally diverse demands through constant interruptions in a fast-paced laboratory environment.
  • Must be self-motivated, take initiative, enjoy learning, and willing to take on new challenges while independently executing new or unusual and complex technical procedures and protocols.
  • Work cooperatively with other personnel as part of a team to accomplish daily and weekly goals.
  • Proficient in PC (or Mac) skills as well as demonstrated proficiency in Microsoft Word, Excel, and PowerPoint.

Working Title: Biomedical Specialist - Applied Genomics, Computation & Translational Core
Department: BMS - Bioinfo & Func Genomics
Business Entity: Cedars-Sinai Medical Center
Job Category: Biomanufacturing
Job Specialty: Biomanufacturing
Position Type: Full-time
Shift Length: 8 hour shift
Shift Type: Day
Base Pay:$71,300.00 - $110,400.00

Our compensation philosophy

We offer competitive total compensation that includes pay, benefits, and other recognition programs for our employees. The base pay range shown above takes into account the wide range of factors that are considered in making compensation decisions including knowledge/skills; relevant experience and training; education/certifications/licensure; and other business and organizational factors. This base pay range does not include our comprehensive benefits package and any incentive payments that may be applicable to this role. Pay Transparency Non Discrimination Provision

Diversity and Inclusion at Cedars-Sinai

We are caretakers and innovators committed to the pursuit of equitable healthcare. But health equity is not possible without representation. Our commitment to diversity goes beyond demographics or checking boxes. Our people must reflect the diverse identities, experiences and geographies of the communities and patients we serve – because that’s what our patients, colleagues and communities deserve. Quality Care and Research—For All, By All.

Cedars-Sinai is an Equal Employment Opportunity employer.

Cedars-Sinai does not unlawfully discriminate on the basis of the race, religion, color, national origin, citizenship, ancestry, physical or mental disability, legally protected medical condition (cancer-related or genetic characteristics or any genetic information), marital status, sex, gender, sexual orientation, gender identity, gender expression, pregnancy, age (40 or older), military and/or veteran status or any other basis protected by federal or state law. If you need a reasonable accommodation for any part of the employment process, please contact us by email at Applicant_Accommodation@cshs.org and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Cedars-Sinai will consider for employment qualified applicants with criminal histories, in accordance with the Los Angeles Fair Chance Initiative for Hiring.

At Cedars-Sinai, we are dedicated to the safety, health and wellbeing of our patients and employees. This includes protecting our patients from communicable diseases, such as influenza (flu) and COVID-19. For this reason, we require that all new employees receive a flu vaccine based on the seasonal availability of flu vaccine (typically during September through April each year) as a condition of employment, and annually thereafter as a condition of continued employment, subject to medical exemption or religious accommodation. For the same reason, you may also be required to receive other vaccines such as COVID-19 as a condition of employment. Cedars-Sinai reserves the right to make modifications to its required list of vaccines as required by law and/or policy. Cedars-Sinai’s AA Policy Statement

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